Edward Calabrese, Professor of Toxicology at the University of Massachusetts, Amherst: Considerable recent ﬁndings have revealed that the linear dose response for cancer risk assessment has not only outlived its utility in predicting risk but is based on a ﬂawed scientiﬁc foundation. The present article characterizes this demise of a key concept of environmental risk assessment, in the framework of a ﬁgurative obituary of a long-lived concept that has poorly served society. This obituary is intended to illustrate an integrated mix of poignant and improper historical judgments that led to both the acceptance and ultimately the demise of this once intellectually facile and nearly universally accepted concept.
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